Florence, capital of Italy's Tuscany region, is home to many masterpieces of Renaissance art and architecture. One of its most iconic sights is the Duomo, a cathedral with a terracotta-tiled dome engineered by Brunelleschi and a bell tower by Giotto. The Galleria dell'Accademia displays Michelangelo's â€œDavid" sculpture. The Uffizi Gallery exhibits Botticelli's â€œThe Birth of Venus" and da Vinci's â€œAnnunciation." Florence originated as a Roman city, and later, after a long period as a flourishing trading and banking medieval commune, it was the birthplace of the Italian Renaissance. According to the EncyclopÃ¦dia Britannica, it was politically, economically, and culturally one of the most important cities in Europe and the world from the 14th to 16th centuries.